Structure of PDB 3lga Chain A

Receptor sequence
>3lgaA (length=253) Species: 272844 (Pyrococcus abyssi GE5) [Search protein sequence]
MIREGDKVVLVDPRGKRYLITVSKRDFHTDLGILKLEEIIGRNFGEAIKS
HKGHEFKILRPRIVDYLDKMKRGPQIVHPKDAALIVAYAGISPGDFIVEA
GVGSGALTLFLANIVGPEGRVVSYEIREDFAKLAWENIKWAGFDDRVTIK
LKDIYEGIEEENVDHVILDLPQPERVVEHAAKALKPGGFFVAYTPCSNQV
MRLHEKLREFKDYFMKPRTINVLVFDQEVKKECMRPRTTALVHTGYITFA
RRI
3D structure
PDB3lga Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.219: tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Q75 I76 V77 G101 G103 A106 L107 E125 I126 D153 I154 Y155 D169 L170 Q75 I76 V77 G101 G103 A106 L107 E125 I126 D153 I154 Y155 D169 L170
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0043827 tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity
GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity
Biological Process
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0031515 tRNA (m1A) methyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3lga, PDBe:3lga, PDBj:3lga
PDBsum3lga
PubMed20483913
UniProtQ9V1J7|TRMI_PYRAB tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI (Gene Name=trmI)

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