Structure of PDB 3lfz Chain A

Receptor sequence

>3lfzA (length=280) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]

MFVRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVG
IITSMDIVDFMGGGSKYNLIREKHERNFLAAINEPVREIMEENVITLKEN
ADIDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVI
DDYITRDVIVATPGERLKDVARTMVRNGFRRLPVVSEGRLVGIITSTDFI
KLLGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGDKLKKIAEIMV
TNDIGALPVVDENLRIKGIITEKDVLKYFA

3D structure

PDB

3lfz The crystal structure of protein MJ1225 from Methanocaldococcus jannaschii shows strong conservation of key structural features seen in the eukaryal gamma-AMPK.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	A	R37 I51 T53 M55 D56 E91 V94 I95 V115 G116 R180	R37 I51 T53 M55 D56 E91 V94 I95 V115 G116 R180
BS02	ADP	A	T155 V158 I159 F179 R180 R181 I269 T271 K273 D274	T155 V158 I159 F179 R180 R181 I269 T271 K273 D274
BS03	ATP	A	R134 R180 R181 I193 T195 T197 D198 V233 I234 G255	R134 R180 R181 I193 T195 T197 D198 V233 I234 G255
BS04	AMP	A	N68 L69 E72 K73 E88	N68 L69 E72 K73 E88

External links

PDB	RCSB:3lfz, PDBe:3lfz, PDBj:3lfz
PDBsum	3lfz
PubMed	20382158
UniProt	Q58622\|Y1225_METJA Uncharacterized protein MJ1225 (Gene Name=MJ1225)

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