Structure of PDB 3lee Chain A

Receptor sequence
>3leeA (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDM
TISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLA
EKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSRL
FSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVW
SRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVF
NFCAIPQVMAIATLAACYNNQQVFKGAVKIDATNMPAVKAIIYQYMEEIY
HRIPDSDPSSSKTRQIISTIRTQN
3D structure
PDB3lee Mechanism of Action (and Inhibition) of Head-to-Head Terpene Synthases: A Structural Investigation
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y171 R218 R228 F288
Catalytic site (residue number reindexed from 1) Y135 R182 R192 F252
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B65 A Y73 R77 D80 V179 Y37 R41 D44 V143
BS02 MG A D80 E83 D84 D44 E47 D48
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3lee, PDBe:3lee, PDBj:3lee
PDBsum3lee
PubMed
UniProtP37268|FDFT_HUMAN Squalene synthase (Gene Name=FDFT1)

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