Structure of PDB 3ldw Chain A

Receptor sequence
>3ldwA (length=358) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
LAFFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNN
RGILVILIYEYVKNRINSSEWEKAACLAWCIEILQAAFLVADDIMDKGEM
RRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATF
RDATLKTIIGQHLDTNIFSDKYSEIDVNNINVPEQPVIDINMINFGVYKN
IVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDD
YLDIFGDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNN
LACVKVIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYL
LEILFTGV
3D structure
PDB3ldw Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
ChainA
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K48 A87 D92 D96 R101 D164 K205 F245 D249 D250
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOL A D126 R135 Q195 K243 T244 D287 K301 D92 R101 Q161 K205 T206 D249 K263 MOAD: Ki=10.7nM
PDBbind-CN: -logKd/Ki=7.97,Ki=10.7nM
BS02 IPE A G80 K81 R84 Q119 R136 F283 D287 G47 K48 R51 Q85 R102 F245 D249
BS03 MG A D126 D130 D92 D96
BS04 MG A D126 D130 D92 D96
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ldw, PDBe:3ldw, PDBj:3ldw
PDBsum3ldw
PubMed21084289
UniProtA5K4U6

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