Structure of PDB 3lcb Chain A

Receptor sequence

>3lcbA (length=554) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]

GLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHL
YDHHVGLVVEQLRCITNEFLLRVKEHYTRLLPDYPRFEIAESFFNSVYCR
LFDHRSLTPERLFIFSSQPRPLAKDFHPDHGWESLLMRVISDLPLRLHWQ
NKSRDIHYIIRHLTETLGPENLSKSHLQVANELFYRNKAAWLVGKLITPS
GTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFMVYAPLPAAL
VEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGCNEQFIEAPG
IRGMVMLVFTLPGFDRVFKVIKDKFAPQKEMSAAHVRACYQLVKEHDRVG
RMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQIVIRHLYIER
RMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDMLFKNFGVTR
HGRVVFYDYDEICYMTEVNFRDIPPPRYPEDELASEPWYSVSPGDVFPEE
FRHWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDVYAYRRRQ
RFSV

3D structure

PDB

3lcb Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AMP	A	N104 S105 H113 L116 K294 T295 Y298 F375 N377	N95 S96 H104 L107 K277 T278 Y281 F358 N360
BS02	ATP	A	G317 I318 G320 M321 V322 V325 V334 K336 K346 M419 P421 K461 N462 Y474 D475 D477	G300 I301 G303 M304 V305 V308 V317 K319 K329 M402 P404 K444 N445 Y457 D458 D460
BS03	MG	A	N462 D475	N445 D458

Gene Ontology

	Molecular Function
GO:0004674	protein serine/threonine kinase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0005524	ATP binding
GO:0008772	[isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208	AMP binding
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016791	phosphatase activity

	Biological Process
GO:0006006	glucose metabolic process
GO:0006097	glyoxylate cycle
GO:0006099	tricarboxylic acid cycle
GO:0006470	protein dephosphorylation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0050790	regulation of catalytic activity

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:3lcb, PDBe:3lcb, PDBj:3lcb
PDBsum	3lcb
PubMed	20505668
UniProt	Q8X607\|ACEK_ECO57 Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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