Structure of PDB 3lc3 Chain A

Receptor sequence
>3lc3A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
3D structure
PDB3lc3 Studies of Benzothiophene Template as Potent Factor IXa (FIXa) Inhibitors in Thrombosis.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D89 Q182 G183 D184 S185 G186
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IYX A D189 S190 C191 Q192 S195 W215 G216 E217 C220 D179 S180 C181 Q182 S185 W205 G206 E207 C209 MOAD: Ki=5.9uM
PDBbind-CN: -logKd/Ki=5.23,Ki=5.9uM
BS02 IYX A K98 Y99 H147 W215 G216 E217 K85 Y86 H135 W205 G206 E207 MOAD: Ki=5.9uM
PDBbind-CN: -logKd/Ki=5.23,Ki=5.9uM
BS03 CA A E70 N72 E75 E77 E80 E55 N57 E60 E62 E65
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3lc3, PDBe:3lc3, PDBj:3lc3
PDBsum3lc3
PubMed20121198
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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