Structure of PDB 3lau Chain A

Receptor sequence
>3lauA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
MKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAG
VEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQ
KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIA
DFLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKR
ISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKP
S
3D structure
PDB3lau Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D256 K258 E260 N261 D274
Catalytic site (residue number reindexed from 1) D133 K135 E137 N138 D151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OFI A L139 V147 E211 Y212 A213 L263 L16 V24 E88 Y89 A90 L140 MOAD: ic50=0.044uM
PDBbind-CN: -logKd/Ki=4.52,IC50=30uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lau, PDBe:3lau, PDBj:3lau
PDBsum3lau
PubMed20167481
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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