Structure of PDB 3l8z Chain A

Receptor sequence
>3l8zA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQH
3D structure
PDB3l8z Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes
ChainA
Resolution1.44 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 F28 V29 D30 E31 P34 T35 G60 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 F28 V29 D30 E31 P34 T35 G60 N116 K117 D119 L120 S145 A146
BS02 MG A S17 T35 S17 T35
BS03 CA A F28 D30 F28 D30
BS04 CA A D107 Y137 D107 Y137
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:3l8z, PDBe:3l8z, PDBj:3l8z
PDBsum3l8z
PubMed20401883
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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