Structure of PDB 3l4p Chain A

Receptor sequence

>3l4pA (length=907) Species: 879 (Megalodesulfovibrio gigas)

MIQKVITVNGIEQNLFVDAEALLSDVLRQQLGLTGVKVGCEQGQCGACSV
ILDGKVVRACVTKMKRVADGAQITTIEGVGQPENLHPLQKAWVLHGGAQC
GFCSPGFIVSAKGLLDTNADPSREDVRDWFQKHRNACRCTGYKPLVDAVM
DAAAVINGKKPETDLEFKMPADGRIWGSKYPRPTAVAKVTGTLDYGADLG
LKMPAGTLHLAMVQAKVSHANIKGIDTSEALTMPGVHSVITHKDVKGKNR
ITGLITFPTNKGDGWDRPILCDEKVFQYGDCIALVCADSEANARAAAEKV
KVDLEELPAYMSGPAAAAEDAIEIHPGTPNVYFEQPIVKGEDTGPIFASA
DVTVEGDFYVGRQPHMPIEPDVAFAYMGDDGKCYIHSKSIGVHLHLYMIA
PGVGLEPDQLVLVANPMGGTFGYKFSPTSEALVAVAAMATGRPVHLRYNY
QQQQQYTGKRSPWEMNVKFAAKKDGTLLAMESDWLVDHGPYSEFGDLLTL
RGAQFIGAGYNIPNIRGLGRTVATNHVWGSAFRGYGAPQSMFASECLMDM
LAEKLGMDPLELRYKNAYRPGDTNPTGQEPEVFSLPDMIDQLRPKYQAAL
EKAQKESTATHKKGVGISIGVYGSGLDGPDASEAWAELNADGTITVHTAW
EDHGQGADIGCVGTAHEALRPMGVAPEKIKFTWPNTATTPNSGPSGGSRQ
QVMTGNAIRVACENLLKACEKPGGGYYTYDELKAADKPTKITGNWTASGA
THCDAVTGLGKPFVVYMYGVFMAEVTVDVATGQTTVDGMTLMADLGSLCN
QLATDGQIYGGLAQGIGLALSEDFEDIKKHATLVGAGFPFIKQIPDKLDI
VYVNHPRPDGPFGASGVGELPLTSPHAAIINAIKSATGVRIYRLPAYPEK
VLEALKA

3D structure

• PDB: 3l4p Correlating EPR and X-ray structural analysis of arsenite-inhibited forms of aldehyde oxidoreductase.
• Chain: A
• Resolution: 1.45 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): I390 F425 R501 F505 R533 E869 L870
• Catalytic site (residue number reindexed from 1): I390 F425 R501 F505 R533 E869 L870
• Enzyme Commision number: 1.2.99.7: aldehyde dehydrogenase (FAD-independent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FES	A	C100 G101 C103 C137 C139	C100 G101 C103 C137 C139
BS02	FES	A	V38 C40 E41 G43 C45 G46 C48 R58 C60	V38 C40 E41 G43 C45 G46 C48 R58 C60
BS03	MG	A	E899 E903	E899 E903
BS04	PCD	A	Q99 C139 G419 T420 F421 G422 R533 H653 G654 Q655 G656 S695 G696 G697 Q700 Q701 C799 N800 T804 Q807 S865 G866 V867 G868 E869	Q99 C139 G419 T420 F421 G422 R533 H653 G654 Q655 G656 S695 G696 G697 Q700 Q701 C799 N800 T804 Q807 S865 G866 V867 G868 E869
BS05	AST	A	Y535 Y622 G696 G697 E869	Y535 Y622 G696 G697 E869

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0033727 aldehyde dehydrogenase (FAD-independent) activity
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding

External links

• PDB: RCSB:3l4p, PDBe:3l4p, PDBj:3l4p
• PDBsum: 3l4p
• PubMed: 17139522
• UniProt: Q46509|MOP_MEGGA Aldehyde oxidoreductase (Gene Name=mop)