Structure of PDB 3l3q Chain A

Receptor sequence

>3l3qA (length=427) Species: 10090 (Mus musculus) [Search protein sequence]

QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

3l3q Probing the specificity of binding to the major nuclear localization sequence-binding site of importin-alpha using oriented peptide library screening.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	L104 S105 E107 P110 F138 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 Y277	L34 S35 E37 P40 F68 W72 N76 S79 G80 T85 Q111 W114 N118 G121 D122 W161 R168 W203 Y207
BS02	peptide	A	G281 N283 V321 T322 T328 W357 S360 N361 A364 E396 W399	G211 N213 V251 T252 T258 W287 S290 N291 A294 E326 W329

External links

PDB	RCSB:3l3q, PDBe:3l3q, PDBj:3l3q
PDBsum	3l3q
PubMed	20406804
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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