Structure of PDB 3l2p Chain A

Receptor sequence

>3l2pA (length=535) Species: 9606 (Homo sapiens)

HMRHKDCLLREFRKLCAMVADNPSYNTKTQIIQDFLRKGGDVYLTVKLLL
PGVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVFFEQS
KSFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKC
IIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNAQEV
ELSVQASLMTPVQPMLAEACKSVEYAMKKCPNGMFSEIKYDGERVQVHKN
GDHFSYFSRSLKPVLPHKVAHFKDYIPQAFPGGHSMILDSEVLLIDNKTG
KPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHD
NMVEIPNRIMFSEMKRVTKALDLADMITRVIQEGLEGLVLKDVKGTYEPG
KRHWLKVKKDYLNMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQK
WCTVTKCAGGHDDATLARLQNELDMVKISKAAVWEITGAEFSKSEAHTAD
GISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSK

3D structure

• PDB: 3l2p Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	V231 N233 N235 K237 Q238 G424 E425 S440 S442 K444 F487	V57 N59 N61 K63 Q64 G242 E243 S258 S260 K262 F305
BS02	dna	A	P190 S191 Y192 N193 R441 R584 K588 Y593 H646 D647 D648 F717 R719	P23 S24 Y25 N26 R259 R402 K406 Y411 H461 D462 D463 F506 R508
BS03	dna	A	T301 K302 E303 N336 G338 H341 Y351 K411 G491 V492 H493 K494 K583 H585 G613 Q614 S616 S622 I623 T640 K641 S703 S705 S714 I715 F717	T127 K128 E129 N162 G164 H167 Y177 K229 G309 V310 H311 K312 K401 H403 G428 Q429 S431 S437 I438 T455 K456 S492 S494 S503 I504 F506
BS04	AMP	A	E419 K421 Y422 F508 K573 W586 K588 K590	E237 K239 Y240 F326 K391 W404 K406 K408

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003909 DNA ligase activity
• GO:0003910 DNA ligase (ATP) activity
• GO:0005524 ATP binding

Biological Process

• GO:0006281 DNA repair
• GO:0006310 DNA recombination
• GO:0071897 DNA biosynthetic process

External links

• PDB: RCSB:3l2p, PDBe:3l2p, PDBj:3l2p
• PDBsum: 3l2p
• PubMed: 20518483
• UniProt: P49916|DNLI3_HUMAN DNA ligase 3 (Gene Name=LIG3)