Structure of PDB 3l0l Chain A

Receptor sequence
>3l0lA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
EAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQR
KSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSAL
HFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQ
SILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB3l0l Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 Q349 I350 P500 L501 E504 S507 K76 Q86 Q89 I90 P240 L241 E244 S247
BS02 peptide A I492 Q495 A496 I232 Q235 A236
BS03 HC3 A Q286 C320 H323 M365 I397 H479 Q26 C60 H63 M105 I137 H219 BindingDB: EC50=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3l0l, PDBe:3l0l, PDBj:3l0l
PDBsum3l0l
PubMed20203100
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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