Structure of PDB 3l0e Chain A

Receptor sequence
>3l0eA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQSNKRSFSDQPKVTPWPLGADPQSRDARQQRF
AHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETAR
RYNHETESITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMSSLGLDDA
EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRF
PRMLMKLVSLRTLSSVHSEQVFALRLADAALPPLLSEIWDVHE
3D structure
PDB3l0e Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V283 K287 R297 E298 I301 K305 P451 L452 E455 D458 E461 V65 K69 R79 E80 I83 K87 P233 L234 E237 D240 E243
BS02 G58 A F268 F271 T272 L274 A275 S278 M312 T316 R319 F329 L330 G344 L345 H435 F50 F53 T54 L56 A57 S60 M94 T98 R101 F111 L112 G126 L127 H217 MOAD: ic50=10nM
PDBbind-CN: -logKd/Ki=8.00,IC50=10nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3l0e, PDBe:3l0e, PDBj:3l0e
PDBsum3l0e
PubMed20345102
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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