Structure of PDB 3kxz Chain A

Receptor sequence
>3kxzA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
WEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLA
EANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLT
INKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLAR
LIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHG
RIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTF
DYLRSVLEDFFTAT
3D structure
PDB3kxz Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.
ChainA
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D364 R366 A368 N369 D382 A400 F402
Catalytic site (residue number reindexed from 1) D127 R129 A131 N132 D145 A163 F165
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A P331 S332 P94 S95
BS02 925 A E249 L251 A271 K273 E288 T316 M319 E320 L371 D382 E12 L14 A34 K36 E51 T79 M82 E83 L134 D145 MOAD: ic50=0.035uM
PDBbind-CN: -logKd/Ki=7.46,IC50=35nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3kxz, PDBe:3kxz, PDBj:3kxz
PDBsum3kxz
PubMed20038108
UniProtP06239|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)

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