Structure of PDB 3kww Chain A

Receptor sequence

>3kwwA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSMRYFYTAMSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRTEPRAP
WIEQEGPEYWDRNTAIFKANTQTYRESLRNLRGYYNQSEAGSHIIQRMYG
CDLGPDGRLLRGHDQSAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAA
RVAEARRAYLEGLCVEWLRRYLENGKETLQRADPPKTHVTHHPVSDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWEP

3D structure

PDB

3kww Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Chain

Resolution

2.18 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	M5 Y7 R62 N63 I66 F67 A69 N70 T73 Y74 S77 N80 Y84 R97 Y99 S116 T143 K146 W147 A150 R156 Y159 W167 Y171	M5 Y7 R62 N63 I66 F67 A69 N70 T73 Y74 S77 N80 Y84 R97 Y99 S116 T143 K146 W147 A150 R156 Y159 W167 Y171

External links

PDB	RCSB:3kww, PDBe:3kww, PDBj:3kww
PDBsum	3kww
PubMed	20483993
UniProt	P01889\|HLAB_HUMAN HLA class I histocompatibility antigen, B alpha chain (Gene Name=HLA-B)

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