Structure of PDB 3kva Chain A

Receptor sequence
>3kvaA (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
PVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVP
KLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKY
FMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPK
PFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLAR
YESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCM
AFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLET
LKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGH
LIKELSKVIRAIEEEN
3D structure
PDB3kva Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.
ChainA
Resolution2.79 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.65: [histone H3]-dimethyl-L-lysine(9) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H282 D284 H354 H169 D171 H241
BS02 FE2 A S249 W250 V251 F369 L370 S136 W137 V138 F256 L257
BS03 AKG A I226 T279 H282 D284 Y292 K299 H354 V356 I113 T166 H169 D171 Y179 K186 H241 V243
External links
PDB RCSB:3kva, PDBe:3kva, PDBj:3kva
PDBsum3kva
PubMed20023638
UniProtQ6ZMT4|KDM7A_HUMAN Lysine-specific demethylase 7A (Gene Name=KDM7A)

[Back to BioLiP]