Structure of PDB 3krb Chain A

Receptor sequence
>3krbA (length=307) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence]
SMQYPPRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRA
FGKIFKDASSGIKREDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLD
LFLVHWPLAFVRNDVGDLFPKDAEGRAMLEKVPLADTWRAMEQLVEEGLV
KHIGVSNYTVPLLADLLNYAKIKPLVNQIEIHPWHPNDATVKFCLDNGIG
VTAYSPMGGSYATQKNVILECKTLKAIADAKGTSPHCVALAWHVKKWNTS
MYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRIRFCDPAIF
WKVPLFD
3D structure
PDB3krb Structure of aldose reductase from Giardia lamblia.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D35 Y40 K71 H104
Catalytic site (residue number reindexed from 1) D36 Y41 K72 H105
Enzyme Commision number 1.1.1.21: aldose reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G10 T11 W12 D35 Y40 H104 Q177 Y203 S204 P205 M206 G208 N222 H242 I261 P262 K263 S264 Q265 T266 R269 N273 G11 T12 W13 D36 Y41 H105 Q178 Y204 S205 P206 M207 G209 N216 H236 I255 P256 K257 S258 Q259 T260 R263 N267
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004032 aldose reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3krb, PDBe:3krb, PDBj:3krb
PDBsum3krb
PubMed21904059
UniProtA8BGX6

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