Structure of PDB 3kn5 Chain A

Receptor sequence
>3kn5A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
KDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN
TQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKK
HFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDLEIKIIDFGF
ARLKPPNGYDESCDLWSLGVILYTMLSGQVPFQCTSAVEIMKKIKKGDFS
FEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNP
LMTPDILGSSGAAVHTCVKATFHAFNKYKREG
3D structure
PDB3kn5 The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D544 K546 N549 D565
Catalytic site (residue number reindexed from 1) D130 K132 N135 D147
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A L432 G433 E434 E499 L500 L501 E548 L551 I564 K716 L18 G19 E20 E85 L86 L87 E134 L137 I146 K269
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3kn5, PDBe:3kn5, PDBj:3kn5
PDBsum3kn5
PubMed20382163
UniProtO75582|KS6A5_HUMAN Ribosomal protein S6 kinase alpha-5 (Gene Name=RPS6KA5)

[Back to BioLiP]