Structure of PDB 3kmr Chain A

Receptor sequence
>3kmrA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSEL
STKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQ
DTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSA
ICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKI
TDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
3D structure
PDB3kmr A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V240 K244 I254 I258 E412 M413 V59 K63 I73 I77 E231 M232
BS02 EQN A F228 L231 S232 C235 L269 I273 F286 S287 F302 V395 L398 F47 L50 S51 C54 L88 I92 F105 S106 F121 V214 L217 BindingDB: Kd=36nM,EC50=2nM,IC50=41nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3kmr, PDBe:3kmr, PDBj:3kmr
PDBsum3kmr
PubMed20543827
UniProtP10276|RARA_HUMAN Retinoic acid receptor alpha (Gene Name=RARA)

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