Structure of PDB 3kmq Chain A

Receptor sequence
>3kmqA (length=476) Species: 12116 (Foot and mouth disease virus C) [Search protein sequence]
GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKSDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH
3D structure
PDB3kmq Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
ChainA
Resolution2.11 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.22.46: L-peptidase.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A L108 D109 M111 E112 R128 R193 H204 G216 C217 N218 S301 A302 T303 Y336 L108 D109 M111 E112 R128 R193 H204 G216 C217 N218 S301 A302 T303 Y336
BS02 rna A Y336 D338 L386 K387 I411 R416 T419 K423 S426 Y336 D338 L386 K387 I411 R416 T419 K423 S426
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3kmq, PDBe:3kmq, PDBj:3kmq
PDBsum3kmq
PubMed20392853
UniProtQ9QCE3

[Back to BioLiP]