Structure of PDB 3kmg Chain A

Receptor sequence
>3kmgA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG
EDKIKEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETMSLHP
LLQEIYKDL
3D structure
PDB3kmg Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T297 K301 L311 Q314 V315 L318 K319 L468 E471 T81 K85 L95 Q98 V99 L102 K103 L251 E254
BS02 538 A F282 G284 C285 Q286 R288 S289 H323 I326 Y327 L330 I341 S342 F363 M364 H449 Y473 F66 G68 C69 Q70 R72 S73 H107 I110 Y111 L114 I125 S126 F147 M148 H233 Y256 BindingDB: EC50=0.8nM,IC50=8nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:3kmg, PDBe:3kmg, PDBj:3kmg
PDBsum3kmg
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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