Structure of PDB 3kmc Chain A

Receptor sequence
>3kmcA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
PDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAW
DNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKML
LEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPNSHGGVCPKAY
YSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDG
LAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQEC
FQERS
3D structure
PDB3kmc The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H405 H409 H415 H186 H190 H196
BS02 INN A G346 T347 L348 G349 N389 Y390 H405 E406 H409 H415 P437 I438 A439 G129 T130 L131 G132 N170 Y171 H186 E187 H190 H196 P218 I219 A220
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3kmc, PDBe:3kmc, PDBj:3kmc
PDBsum3kmc
PubMed20022498
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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