Structure of PDB 3klv Chain A

Receptor sequence

>3klvA (length=476) Species: 12116 (Foot and mouth disease virus C)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKSDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGIPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH

3D structure

• PDB: 3klv Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	L108 D109 T115 A116 R128 F162 K164 D165 V181 I189 R193 H204 G216 C217 N218 G299 C300 A302 T303	L108 D109 T115 A116 R128 F162 K164 D165 V181 I189 R193 H204 G216 C217 N218 G299 C300 A302 T303
BS02	rna	A	S304 Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426	S304 Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426
BS03	MG	A	D63 E293	D63 E293

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:3klv, PDBe:3klv, PDBj:3klv
• PDBsum: 3klv
• PubMed: 20392853
• UniProt: Q9QCE3