Structure of PDB 3kh5 Chain A

Receptor sequence

>3kh5A (length=278) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]

VRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVGII
TSMDIVDFMGGGSKYNLIREKHERNFLAAINEPVREIMEENVITLKENAD
IDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVIDD
YITRDVIVATPGERLKDVARTMVRNGFRRLPVVSEGRLVGIITSTDFIKL
LGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGDKLKKIAEIMVTN
DIGALPVVDENLRIKGIITEKDVLKYFA

3D structure

PDB

3kh5 The crystal structure of protein MJ1225 from Methanocaldococcus jannaschii shows strong conservation of key structural features seen in the eukaryal gamma-AMPK.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	A	Q10 I14 V15 Y35 R37 T132 R134 D135 R180	Q8 I12 V13 Y33 R35 T130 R132 D133 R178
BS02	AMP	A	R181 T195 T197 D198 V233 I234	R179 T193 T195 D196 V231 I232
BS03	ADP	A	R37 I51 T53 M55 D56 E91 V94 I95 V115 G116 R180	R35 I49 T51 M53 D54 E89 V92 I93 V113 G114 R178
BS04	ADP	A	T155 V158 I159 F179 R180 R181 T271 K273 D274	T153 V156 I157 F177 R178 R179 T269 K271 D272
BS05	AMP	A	N68 L69 E72 K73 E88	N66 L67 E70 K71 E86

External links

PDB	RCSB:3kh5, PDBe:3kh5, PDBj:3kh5
PDBsum	3kh5
PubMed	20382158
UniProt	Q58622\|Y1225_METJA Uncharacterized protein MJ1225 (Gene Name=MJ1225)

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