Structure of PDB 3ker Chain A

Receptor sequence
>3kerA (length=117) Species: 10090 (Mus musculus) [Search protein sequence]
PFVELETNLPASRIPAGLENRLCAATATILDKPEDRVSVTIRPGMTLLMN
KSTEPCAHLLVSSIGVVGTAEQNRTHSASFFKFLTEELSLDQDRIVIRFF
PLEAWQIGKKGTVMTFL
3D structure
PDB3ker Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
ChainA
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.84: D-dopachrome decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RW1 A P1 F2 R36 K109 M114 P1 F2 R36 K109 M114
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0016829 lyase activity
GO:0033981 D-dopachrome decarboxylase activity
Biological Process
GO:0042438 melanin biosynthetic process
GO:0050729 positive regulation of inflammatory response
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ker, PDBe:3ker, PDBj:3ker
PDBsum3ker
PubMed25016026
UniProtO35215|DOPD_MOUSE D-dopachrome decarboxylase (Gene Name=Ddt)

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