Structure of PDB 3ken Chain A

Receptor sequence
>3kenA (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYT
FDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEG
ERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEE
LFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG
AAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLA
GSENINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSII
ATISPASLNLEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB3ken Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R26 P27 T107 G108 G110 K111 T112 F113 R9 P10 T90 G91 G93 K94 T95 F96
BS02 ZZD A E116 G117 E118 R119 A133 P137 Y211 L214 E215 E99 G100 E101 R102 A116 P120 Y194 L197 E198 PDBbind-CN: -logKd/Ki=5.40,IC50=4uM
BindingDB: IC50=1000nM,EC50=1720nM,Ki=143.8nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:3ken, PDBe:3ken, PDBj:3ken
PDBsum3ken
PubMed20299460
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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