Structure of PDB 3kdz Chain A

Receptor sequence
>3kdzA (length=527) Species: 1908 (Streptomyces globisporus) [Search protein sequence]
VPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNI
PIFGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIV
AARLNTLAKGHSAVRPIILERLAQYLNEGITPAIPEIGSLGGDLAPLSHV
ASTLIGEGYVLRDGRPVETAQVLAERGIEPLELRFKEGLALINGTSGMTG
LGSLVVGRALEQAQQAEIVTALLIEAVRGSTSPFLAEGHDIARPHEGQID
TAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRSEIYLQKAYSLRA
IPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQPIA
FAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAG
AQYPATALVAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNN
NKILAVEYLAAAQAVDISGRFDGLSPAAKATYEAVRRLVPTLGVDRYMAD
DIELVADALSRGEFLRAIARETDIQLR
3D structure
PDB3kdz Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F63 G70 H93 N205 Y308 R311 F356 Q442
Catalytic site (residue number reindexed from 1) F53 G60 H83 N193 Y296 R299 F344 Q430
Enzyme Commision number 4.3.1.23: tyrosine ammonia-lyase.
5.4.3.6: tyrosine 2,3-aminomutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR A F63 Y69 G70 H93 X152 N205 F356 F53 Y59 G60 H83 X142 N193 F344
BS02 TYR A Y308 R311 Y296 R299
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016829 lyase activity
GO:0016841 ammonia-lyase activity
GO:0016853 isomerase activity
GO:0050368 L-tyrosine 2,3-aminomutase activity
GO:0052883 tyrosine ammonia-lyase activity
Biological Process
GO:0006548 L-histidine catabolic process
GO:0009403 toxin biosynthetic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3kdz, PDBe:3kdz, PDBj:3kdz
PDBsum3kdz
PubMed20577998
UniProtQ8GMG0|TAM_STRGL MIO-dependent tyrosine 2,3-aminomutase

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