Structure of PDB 3kba Chain A

Receptor sequence
>3kbaA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
QLIPPLINLLMSIEPDVIYAGHDTSSSLLTSLNQLGERQLLSVVKWSKSL
PGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNE
QRMKEFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQ
TQFEEMRSSYIRELIKAIGLRKGVVSSSQRFYQLTKLLDNLHDLVKQLHL
YCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK
3D structure
PDB3kba Improving the developability profile of pyrrolidine progesterone receptor partial agonists.
ChainA
Resolution2.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WOW A L715 L718 N719 L721 M759 V760 F778 F794 M801 L887 Y890 C891 F905 L29 L32 N33 L35 M73 V74 F92 F106 M113 L198 Y201 C202 F216 MOAD: ic50=16nM
PDBbind-CN: -logKd/Ki=7.80,IC50=16nM
BindingDB: IC50=16nM,EC50=25nM
External links
PDB RCSB:3kba, PDBe:3kba, PDBj:3kba
PDBsum3kba
PubMed19926282
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

[Back to BioLiP]