Structure of PDB 3k9n Chain A

Receptor sequence
>3k9nA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEFDPTIEDSYRKQVVIDGET
CLLDILDTAGQYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKR
VKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGV
EDAFYTLVREIRQH
3D structure
PDB3k9n Allosteric modulation of Ras positions Q61 for a direct role in catalysis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 D30 E31 N116 K117 D119 L120 S145 A146 K147 G13 G15 K16 S17 A18 D30 E31 N114 K115 D117 L118 S143 A144 K145
BS02 CA A R102 D105 R100 D103
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k9n, PDBe:3k9n, PDBj:3k9n
PDBsum3k9n
PubMed20194776
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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