Structure of PDB 3k8t Chain A

Receptor sequence
>3k8tA (length=640) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDR
DFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALET
YNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECA
LISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQG
GPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRV
EENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSI
LEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAV
CNLASVALPAFIEKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARK
SNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETIYHASMEAS
CELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGV
RNSLTMAPMPTASTSQILGYNECFEPVTSNMYQVVNPYLLRDLVDLGIWD
EGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINMAADRSVYI
DQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQ
3D structure
PDB3k8t Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C129 N334 C336 E338 C351 Y635 Y636
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT A D226 S227 I228 R256 I262 A263 G264 D137 S138 I139 R167 I173 A174 G175
BS02 2A5 A A201 S202 S217 C218 G246 G247 N426 L427 C428 E430 L445 P607 T608 A609 S610 T611 A112 S113 S128 C129 G157 G158 N334 L335 C336 E338 L353 P510 T511 A512 S513 T514
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k8t, PDBe:3k8t, PDBj:3k8t
PDBsum3k8t
PubMed19681093
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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