Structure of PDB 3k5i Chain A

Receptor sequence
>3k5iA (length=381) Species: 5057 (Aspergillus clavatus) [Search protein sequence]
MWNSRKVGVLGGGQLGRMLVESANRLNIQVNVLDADNSPAKQISAHDGHV
TGSFKEREAVRQLAKTCDVVTAEIEHVDTYALEEVASEVKIEPSWQAIRT
IQNKFNQKEHLRKYGIPMAEHRELVENTPAELAKVGEQLGYPLMLKSKTM
AYDGRGNFRVNSQDDIPEALEALKDRPLYAEKWAYFKMELAVIVVKTKDE
VLSYPTVETVQEDSICKLVYAPARNVSDAINQKAQELARKAVAAFDGKGV
FGVEMFLLEDDSIMLCEIASRIHNSGHYTIEGCALSQFDAHLRAILDLPI
PAQSLEIRQPSIMLNIIGGAAPDTHLQAAECALSIPNASIHLYSKGAAKP
GRKMGHITVTAPTMHEAETHIQPLIDVVDRI
3D structure
PDB3k5i Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E254 E267 N274 S275 K353
Catalytic site (residue number reindexed from 1) E254 E267 N274 S275 K353
Enzyme Commision number 4.1.1.21: phosphoribosylaminoimidazole carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A K104 K146 Y152 D153 G154 W183 A184 F186 E189 Q211 S214 E267 K104 K146 Y152 D153 G154 W183 A184 F186 E189 Q211 S214 E267
BS02 MG A E254 E267 E254 E267
BS03 AIR A G13 Q14 L15 E73 I74 Y152 D153 R155 R271 K345 R352 G13 Q14 L15 E73 I74 Y152 D153 R155 R271 K345 R352
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006189 'de novo' IMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3k5i, PDBe:3k5i, PDBj:3k5i
PDBsum3k5i
PubMed20050602
UniProtA1CII2

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