Structure of PDB 3k3h Chain A

Receptor sequence
>3k3hA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
YLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTL
RRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILIL
MTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAE
PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYS
NEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEG
LPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWE
SRDRYEELKRIDDAMKELQK
3D structure
PDB3k3h Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H256 H292 D293 D402 H71 H107 D108 D217
BS02 BYE A H252 L420 Y424 F441 Q453 F456 H67 L235 Y239 F256 Q268 F271 PDBbind-CN: -logKd/Ki=7.06,IC50=88nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3k3h, PDBe:3k3h, PDBj:3k3h
PDBsum3k3h
PubMed20121115
UniProtO76083|PDE9A_HUMAN High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Gene Name=PDE9A)

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