Structure of PDB 3k2p Chain A

Receptor sequence
>3k2pA (length=131) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
YQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQK
TELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLI
KKEKVYLAWVPAHKGIGGNEQVDKLVSAGIR
3D structure
PDB3k2p Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D443 E478 D498 D17 E52 D72
BS02 MN A D443 D549 D17 D123
BS03 JTH A D443 H539 R557 D17 H113 R131 MOAD: Kd=6uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:3k2p, PDBe:3k2p, PDBj:3k2p
PDBsum3k2p
PubMed20004166
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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