Structure of PDB 3k24 Chain A

Receptor sequence
>3k24A (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSAWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVK
MAKDRRNHCGIASAASYPTV
3D structure
PDB3k24 Structural basis for the recognition and cleavage of histone H3 by cathepsin L.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 A25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 A25 H163 N187
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G23 A25 G67 G68 M70 A135 G23 A25 G67 G68 M70 A135
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3k24, PDBe:3k24, PDBj:3k24
PDBsum3k24
PubMed21326229
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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