Structure of PDB 3k23 Chain A

Receptor sequence
>3k23A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
LPQLTPTLVSLLEVIEPEVLYAGYDSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAP
DLIINEQGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGL
KSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVE
NLLNYCFQTFLDKMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3k23 Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 M593 Q597 E751 M752 E755 V50 K54 M68 Q72 E220 M221 E224
BS02 peptide A Y648 E652 K720 Y118 E122 K190
BS03 JZN A P541 M560 L563 N564 L566 Q570 M601 L603 M604 A605 A607 L608 F623 C736 P17 M35 L38 N39 L41 Q45 M76 L78 M79 A80 A82 L83 F98 C206 PDBbind-CN: -logKd/Ki=8.20,IC50=6.3nM
BindingDB: IC50=6.3nM
External links
PDB RCSB:3k23, PDBe:3k23, PDBj:3k23
PDBsum3k23
PubMed19822747
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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