Structure of PDB 3k22 Chain A

Receptor sequence
>3k22A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSANLLCFAPD
LIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP
KDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMH
EVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3k22 Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 L589 M593 M752 E755 V50 K54 L64 M68 M226 E229
BS02 JZS A L563 N564 L566 G567 Q570 A574 M601 M604 A607 F623 F749 L38 N39 L41 G42 Q45 A49 M76 M79 A82 F97 F223 PDBbind-CN: -logKd/Ki=7.90,IC50=12.59nM
BS03 JZR A T556 M560 P637 G638 Y735 T31 M35 P111 G112 Y209
External links
PDB RCSB:3k22, PDBe:3k22, PDBj:3k22
PDBsum3k22
PubMed19822747
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]