Structure of PDB 3k1l Chain A

Receptor sequence
>3k1lA (length=376) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
EDVERLLCQKYPGLAAELQPSGACIIRGVLGSEDTWRRLKLYLPHHPALH
GFQLYVQESLEYKLYTSANLKLQDDWLLEDFLDHLPKILPAQKAPTVPEL
CREGNIYYDILALYKSNEYCLQVDEACSMIRFSEFTDFEQHYLELKIPSL
LLLDHSLPDCVSLGEMLTKSAGNLEEALNLFRKLLEDLRPFYDNFMDIDE
LCHVLQPSPISSKHKTRLFPLKDRVYLKLTIADPFACIASMSLKIIGPTE
EVARLRHVLSDGLSNWDSEMNIHKNLLRMFDLCYFPMPDWSDGPKLDEED
NEELRCNICFAYRLDGGEVPLVSCDNAKCVLKCHAVCLEEWFKTLMDGKT
FLEVSFGQCPFCKAKLSTSFAALLND
3D structure
PDB3k1l The structure of the catalytic subunit FANCL of the Fanconi anemia core complex
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A M292 D294 S296 M287 D289 S291
BS02 ZN A C329 C334 C364 C367 C324 C329 C359 C362
BS03 ZN A C311 H339 C306 H334
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0016567 protein ubiquitination
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0043240 Fanconi anaemia nuclear complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3k1l, PDBe:3k1l, PDBj:3k1l
PDBsum3k1l
PubMed20154706
UniProtQ8T913|FANCL_DROME E3 ubiquitin-protein ligase Fancl (Gene Name=Fancl)

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