Structure of PDB 3jzc Chain A

Receptor sequence
>3jzcA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
EELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIG
QVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEI
MSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSS
FNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKH
HVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB3jzc Gaining ligand selectivity in thyroid hormone receptors via entropy.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4HY A F269 F272 I276 A279 M313 L330 N331 L346 H435 F455 F57 F60 I64 A67 M101 L118 N119 L134 H223 F243 MOAD: ic50~1nM
PDBbind-CN: -logKd/Ki=8.53,IC50=2.94nM
BindingDB: IC50=0.0407nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3jzc, PDBe:3jzc, PDBj:3jzc
PDBsum3jzc
PubMed19926848
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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