Structure of PDB 3jzb Chain A

Receptor sequence
>3jzbA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLP
DDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELP
CEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLG
VVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQE
AYLLAFEHYVNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECP
TELFPPLFLEVFED
3D structure
PDB3jzb Gaining ligand selectivity in thyroid hormone receptors via entropy.
ChainA
Resolution2.007 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4HY A F215 F218 I222 M256 M259 A263 R266 L276 S277 L292 H381 F72 F75 I79 M113 M116 A120 R123 L133 S134 L149 H238 MOAD: ic50~0.1nM
PDBbind-CN: -logKd/Ki=9.01,IC50=0.97nM
BindingDB: IC50=0.14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3jzb, PDBe:3jzb, PDBj:3jzb
PDBsum3jzb
PubMed19926848
UniProtP10827|THA_HUMAN Thyroid hormone receptor alpha (Gene Name=THRA)

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