Structure of PDB 3jwr Chain A

Receptor sequence
>3jwrA (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
TRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQ
NFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQN
KLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHF
DQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFF
ELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEF
WEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTQLYEALTHVS
EDCFPLLDGCRKNRQKWQALAEQ
3D structure
PDB3jwr Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
ChainA
Resolution2.994 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Q666 H678 A726 I802 G819 F823 Q130 H142 A190 I266 G283 F287
BS02 ZN A H617 H653 D654 D764 H81 H117 D118 D228
BS03 MG A D654 E682 D118 E146
BS04 IBM A H613 F786 Q817 F820 H77 F250 Q281 F284 PDBbind-CN: -logKd/Ki=8.07,Ki=8.5nM
BS05 IBM A L701 S702 L704 Y709 L165 S166 L168 Y173 PDBbind-CN: -logKd/Ki=8.07,Ki=8.5nM
BS06 IBM A D687 L690 D151 L154 PDBbind-CN: -logKd/Ki=8.07,Ki=8.5nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3jwr, PDBe:3jwr, PDBj:3jwr
PDBsum3jwr
PubMed19798052
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A);
P51160

[Back to BioLiP]