Structure of PDB 3jwq Chain A

Receptor sequence
>3jwqA (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
ETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLV
QNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQ
NKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHH
FDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEF
FELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATE
FWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTQLYEALTHV
SEDCFPLLDGCRKNRQKWQALAEQ
3D structure
PDB3jwq Structural basis of phosphodiesterase 6 inhibition by the C-terminal region of the gamma-subunit
ChainA
Resolution2.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H617 H653 D654 D764 H82 H118 D119 D229
BS02 VIA A M804 Q817 F820 M269 Q282 F285 PDBbind-CN: -logKd/Ki=7.60,Ki=25nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3jwq, PDBe:3jwq, PDBj:3jwq
PDBsum3jwq
PubMed19798052
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A);
P51160

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