Structure of PDB 3ju8 Chain A

Receptor sequence

>3ju8A (length=486) Species: 287 (Pseudomonas aeruginosa)

MMSTHYIAGQWLAGQGETLESLDPVGQGVVWSGRGADATQVDAAVCAARE
AFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESATEV
TSMVNKVAISVQAFRERTGEKSGPLADATAVLRHKPHGVVAVFGPYNFPG
HLPNGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQ
GGRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNN
PLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLARL
VAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAM
TQPIDGAALLTPGILDVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANA
TQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGAS
GNHRPSAYYAADYCAYPVASLESPSVSLPATLTPGI

3D structure

• PDB: 3ju8 Crystal Structure of Succinylglutamic Semialdehyde Dehydrogenase from Pseudomonas aeruginosa
• Chain: A
• Resolution: 1.82 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N147 K170 E245 C279 E377 P455
• Catalytic site (residue number reindexed from 1): N147 K170 E245 C279 E377 P455
• Enzyme Commision number: 1.2.1.71: succinylglutamate-semialdehyde dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G144 Y146 N147 L152 K170 S172 F220 T221 G222 S223 T226 E245 M246 G247 C279 E377 F379 F444	G144 Y146 N147 L152 K170 S172 F220 T221 G222 S223 T226 E245 M246 G247 C279 E377 F379 F444

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0043824 succinylglutamate-semialdehyde dehydrogenase activity

Biological Process

• GO:0006525 arginine metabolic process
• GO:0006527 arginine catabolic process
• GO:0019544 arginine catabolic process to glutamate
• GO:0019545 arginine catabolic process to succinate

External links

• PDB: RCSB:3ju8, PDBe:3ju8, PDBj:3ju8
• PDBsum: 3ju8
• UniProt: O50174|ASTD_PSEAE N-succinylglutamate 5-semialdehyde dehydrogenase (Gene Name=astD)