Structure of PDB 3jru Chain A

Receptor sequence

>3jruA (length=490) Species: 64187 (Xanthomonas oryzae pv. oryzae)

MALQFTLNQDAPASAAVDCIVVGAFADKTLSPAAQALDSASQGRLTALLA
RGDVAGKTGSTTLLHDLPGVAAPRVLVVGLGDAGKFGVAPYLKAIGDATR
ALKTGAVGTALLTLTELTVKARDAAWNIRQAVTVSDHAAYRYTATLGKKK
VDETGLTTLAIAGDDARALAVGVATAEGVEFARELGNLPPNYCTPAYLAD
TAAAFAGKFPGAEAEILDEAQMEALGMGSLLSVARGSANRPRLIVLKWNG
GGDARPYVLVGKGITFDTGGVNLKTQGGIEEMKYDMCGGATVIGTFVATV
KAELPINLVVVVPAVENAIDGNAYRPSDVITSMSGKTIEVGNTDAEGRLI
LCDALTYAERFNPEALVDVATLTGACMVALGHQTAGLMSKHDDLANELLA
AGEHVFDRAWRLPLWDEYQGLLDSTFADVYNIGGRWGGAITAGCFLSRFT
ENQRWAHLDIAGVASDEGKRGMATGRPVGLLTQWLLDRAA

3D structure

• PDB: 3jru Crystal structure of Leucyl Aminopeptidase (pepA) from Xoo0834,Xanthomonas oryzae pv. oryzae KACC10331
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K274 R348
• Catalytic site (residue number reindexed from 1): K274 R348
• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.11.10: bacterial leucyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CO3	A	A345 E346 G347 R348 L372	A345 E346 G347 R348 L372
BS02	ZN	A	D267 D344 E346	D267 D344 E346
BS03	ZN	A	K262 D285 E346	K262 D285 E346

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3jru, PDBe:3jru, PDBj:3jru
• PDBsum: 3jru
• UniProt: Q5H4N2|AMPA_XANOR Probable cytosol aminopeptidase (Gene Name=pepA)