Structure of PDB 3jpx Chain A

Receptor sequence
>3jpxA (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG
EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG
GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY
NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVC
WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALG
NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCD
DASIWRWDR
3D structure
PDB3jpx Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F97 Y148 N307 C324 D362 I363 W364 Y365 R414 F17 Y68 N227 C244 D282 I283 W284 Y285 R334
Gene Ontology
Molecular Function
GO:0001222 transcription corepressor binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0031491 nucleosome binding
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0021510 spinal cord development
GO:0031507 heterochromatin formation
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0035098 ESC/E(Z) complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3jpx, PDBe:3jpx, PDBj:3jpx
PDBsum3jpx
PubMed20974918
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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