Structure of PDB 3jca Chain A

Receptor sequence
>3jcaA (length=262) Species: 11757 (Mouse mammary tumor virus) [Search protein sequence]
ALESAQESHALHHQNAAALRFQFHITREQAREIVKLCPNCPHAPQLGVNP
RGLKPRVLWQMDVTHVSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVL
QHLAQSFAYMGIPQKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQG
QAIVERTHQNIKAQLNKLQKAGKYYTPHHLLAHALFVLNHVNMDNQGHTA
AERHWGPISADPKPMVMWKDLLTGSWKGPDVLITAGRGYACVFPQDAESP
IWVPDRFIRPFT
3D structure
PDB3jca Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
ChainA
Resolution4.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G50 V51 N52 P53 R54 H87 K120 G146 I147 Q152 R159 G47 V48 N49 P50 R51 H84 K117 G143 I144 Q149 R156
BS02 dna A Q152 E158 R159 Q162 R240 Q149 E155 R156 Q159 R237
BS03 dna A R31 H45 R259 R262 R31 H42 R256 R259
BS04 dna A R20 R27 H45 R20 R27 H42
BS05 ZN A H9 H13 C37 H9 H13 C37
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3jca, PDBe:3jca, PDBj:3jca
PDBsum3jca
PubMed26887496
UniProtP03365|POL_MMTVB Gag-Pro-Pol polyprotein (Gene Name=gag-pro-pol)

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