Structure of PDB 3iwy Chain A

Receptor sequence
>3iwyA (length=82) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNL
3D structure
PDB3iwy D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms.
ChainA
Resolution1.93 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 F55 G58 I61 Y67 Q72 V75 V93 Y100 L29 F30 G33 I36 Y42 Q47 V50 V68 Y75
BS02 peptide A E95 H96 R97 E70 H71 R72
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3iwy, PDBe:3iwy, PDBj:3iwy
PDBsum3iwy
PubMed20660730
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

[Back to BioLiP]