Structure of PDB 3iur Chain A

Receptor sequence
>3iurA (length=668) Species: 648 (Aeromonas caviae) [Search protein sequence]
LHYPVTRQGEQVDHYFGQAVADPYRWLEDDRSPETEAWVKAQNAVTQDYL
AQIPYRAAIKEKLAASWNYAKEGAPFREGRYHYFFKNDGLQNQNVLWRQQ
EGKPAEVFLDPNTLSPDGTTALDQLSFSRDGRILAYSLSLAGSDWREIHL
MDVESKQPLETPLKDVKFSGISWLGNEGFFYSSYDKPTDQHKVYFHRLGT
AQEDDRLVFGAIPAQHHRYVGATVTEDDRFLLISAANSTSGNRLYVKDLS
QENAPLLTVQGDLDADVSLVDNKGSTLYLLTNRDAPNRRLVTVDAANPGP
AHWRDLIPERQQVLTVHSGSGYLFAEYMVDATARVEQFDYEGKRVREVAL
PGLGSVSGFNGKHDDPALYFGFENYAQPPTLYRFEPKSGAISLYRASAAP
FKPEDYVSEQRFYQSKDGTRVPLIISYRKGLKLDGSNPTILYGYGGFDVS
LTPSFSVSVANWLDLGGVYAVANLRGGGEYGQAWHLAGTQQNKQNVFDDF
IAAAEYLKAEGYTRTDRLAIRGGSNGGLLVGAVMTQRPDLMRVALPAVGV
LDMLRYHTFTAGTGWAYDYGTSADSEAMFDYLKGYSPLHNVRPGVSYPST
MVTTADHNDRVVPAHSFKFAATLQADNAGPHPQLIRIETPVAKLIEQSAD
IYAFTLYEMGYRELPRQP
3D structure
PDB3iur Induced-fit mechanism for prolyl endopeptidase
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y458 S538 N622
Catalytic site (residue number reindexed from 1) Y444 S524 N608
Enzyme Commision number 3.4.21.26: prolyl oligopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N296 P300 N301 D462 Y494 N282 P286 N287 D448 Y480
BS02 peptide A N301 E323 R324 Q325 G495 Q496 N287 E309 R310 Q311 G481 Q482
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3iur, PDBe:3iur, PDBj:3iur
PDBsum3iur
PubMed20444688
UniProtQ9X6R4

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