Structure of PDB 3ips Chain A

Receptor sequence
>3ipsA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
QLSPEQLGMIEKLVAAQQVTPWPSREARQQRFAHFTELAIVSVQEIVDFA
KQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYN
REDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNV
QDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHS
EQVFALRLQDKKLPPLLSEIWDVH
3D structure
PDB3ips X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V269 K273 E284 I287 A288 K291 P437 L438 E441 V47 K51 E62 I65 A66 K69 P215 L216 E219
BS02 O90 A F257 L260 S264 M298 E301 T302 R305 F315 F335 W443 F35 L38 S42 M76 E79 T80 R83 F93 F113 W221 MOAD: Ki=64nM
PDBbind-CN: -logKd/Ki=7.19,Ki=64nM
BindingDB: EC50=35nM,IC50=32nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3ips, PDBe:3ips, PDBj:3ips
PDBsum3ips
PubMed20382159
UniProtQ13133|NR1H3_HUMAN Oxysterols receptor LXR-alpha (Gene Name=NR1H3)

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