Structure of PDB 3io9 Chain A

Receptor sequence
>3io9A (length=142) Species: 9606,10090 [Search protein sequence]
DDLYRQSLEIISRYLREQATGSGAAGRRALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKT
INQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVE
3D structure
PDB3io9 Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V220 H224 G230 M231 K234 V249 H252 V253 D256 N260 G262 R263 T266 L267 F270 F318 F319 V40 H44 G50 M51 K54 V69 H72 V73 D76 N80 G82 R83 T86 L87 F90 F138 F139
BS02 ZN A D313 E317 D133 E137
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3io9, PDBe:3io9, PDBj:3io9
PDBsum3io9
PubMed19726685
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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