Structure of PDB 3imy Chain A

Receptor sequence
>3imyA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
MEELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDI
GQKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCM
EIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYR
KHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
D
3D structure
PDB3imy Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
ChainA
Resolution2.55 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B72 A A279 R282 M310 M313 L330 N331 L346 H435 F455 A69 R72 M100 M103 L120 N121 L136 H225 F245 PDBbind-CN: -logKd/Ki=9.70,Kd=0.2nM
BindingDB: Kd=0.1nM,Ki=0.32nM,EC50=2.82nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3imy, PDBe:3imy, PDBj:3imy
PDBsum3imy
PubMed18237438
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

[Back to BioLiP]